Cynthia E Dunbar Selected Research

eltrombopag

1/2022	Long-term eltrombopag for bone marrow failure depletes iron.
1/2022	Studies of a mosaic patient with DBA and chimeric mice reveal erythroid cell-extrinsic contributions to erythropoiesis.
12/2020	Eltrombopag monotherapy can improve hematopoiesis in patients with low to intermediate risk-1 myelodysplastic syndrome.
1/2020	Eltrombopag for patients with moderate aplastic anemia or uni-lineage cytopenias.
1/2019	Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ.
1/2019	Treatment optimization and genomic outcomes in refractory severe aplastic anemia treated with eltrombopag.
1/2018	Eltrombopag mobilizes iron in patients with aplastic anemia.
1/2017	Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia.
3/2014	Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug.
7/2013	Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromes.

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Cynthia E Dunbar Research Topics

Disease

12	Aplastic Anemia (Anemia, Hypoplastic) 01/2022 - 07/2012
8	Neoplasms (Cancer) 10/2019 - 06/2006
7	Leukemia 01/2018 - 03/2004
5	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 01/2022 - 01/2003
4	Bone Marrow Failure Disorders 01/2022 - 07/2013
3	Chronic Granulomatous Disease 12/2020 - 06/2006
3	Cytopenia 12/2020 - 06/2010
3	Hemorrhage 07/2013 - 01/2003
3	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2012 - 06/2005
2	Hemoglobinopathies 01/2021 - 10/2016
2	Infections 12/2020 - 01/2019
2	Bacterial Infections (Bacterial Infection) 12/2020 - 11/2006
2	Thrombocytopenia (Thrombopenia) 12/2020 - 03/2006
2	Hemophilia A (Haemophilia) 12/2018 - 07/2012
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2018 - 05/2006
2	Pancytopenia 07/2012 - 06/2010
2	Graft vs Host Disease (Graft-Versus-Host Disease) 06/2011 - 08/2002
2	Opportunistic Infections (Opportunistic Infection) 07/2007 - 03/2005
2	X-Linked Combined Immunodeficiency Diseases (X Linked Severe Combined Immunodeficiency) 06/2006 - 03/2004
1	Anemia 01/2022
1	Iron-Deficiency Anemia (Anemia, Iron Deficiency) 01/2022
1	Iron Overload 01/2022
1	Glucocorticoid Receptor Deficiency 12/2020
1	Fibrosis (Cirrhosis) 12/2020
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 12/2020
1	Dyskeratosis Congenita (X-Linked Dyskeratosis Congenita) 10/2019
1	Ectodermal Dysplasia (Aplasia Cutis Congenita) 10/2019
1	Hematologic Diseases (Blood Diseases) 12/2018
1	Immune System Diseases (Immune Disorders) 12/2018
1	Cardiomyopathies (Cardiomyopathy) 12/2018
1	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2018
1	Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria) 07/2018
1	Hypereosinophilic Syndrome (Loeffler Endocarditis) 01/2018
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2018
1	Inborn Genetic Diseases (Disease, Hereditary) 10/2016
1	Carcinogenesis 01/2015
1	Eosinophilia 06/2014
1	Chromosome Aberrations (Chromosome Abnormalities) 03/2014
1	Teratoma (Teratoid Tumor) 01/2014
1	Myeloid Leukemia (Leukemia, Myelocytic) 10/2011
1	Endomyocardial Fibrosis 11/2007
1	Pdgfra-Associated Chronic Eosinophilic Leukemia 11/2007

Drug/Important Bio-Agent (IBA)

11	eltrombopag FDA Link 01/2022 - 07/2012
5	Thrombopoietin (c-mpl Ligand)IBA 12/2020 - 07/2012
4	Imatinib Mesylate (Gleevec)FDA Link 06/2014 - 08/2002
3	IronIBA 01/2022 - 01/2018
3	CytokinesIBA 01/2019 - 06/2004
3	Pharmaceutical PreparationsIBA 12/2018 - 05/2006
2	Anti-Bacterial Agents (Antibiotics)IBA 12/2020 - 01/2003
2	Messenger RNA (mRNA)IBA 12/2020 - 10/2011
2	Thrombopoietin ReceptorsIBA 12/2020 - 01/2017
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2020 - 01/2018
2	Telomerase (Telomerase Reverse Transcriptase)IBA 10/2019 - 05/2013
2	Proteins (Proteins, Gene)FDA Link 10/2019 - 07/2018
2	AntibodiesIBA 07/2018 - 07/2012
2	Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)IBA 06/2014 - 08/2002
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 11/2005 - 08/2002
1	Ribosomal Proteins (Ribosomal Protein)IBA 01/2022
1	Ferritins (Ferritin)IBA 01/2022
1	Heme (Haem)IBA 01/2022
1	NADP (NADPH)IBA 12/2020
1	NADPH Oxidases (NAD(P)H oxidase)IBA 12/2020
1	GlucocorticoidsIBA 12/2020
1	Reticulin (Reticular Fiber)IBA 12/2020
1	HoloenzymesIBA 10/2019
1	InterferonsIBA 01/2019
1	aerolysinIBA 07/2018
1	DexpramipexoleIBA 01/2018
1	AntigensIBA 01/2018
1	SteroidsIBA 01/2018
1	Chimeric Antigen ReceptorsIBA 01/2018
1	Intracellular Signaling Peptides and ProteinsIBA 01/2017
1	Syk KinaseIBA 01/2017
1	Transcription Factors (Transcription Factor)IBA 01/2017
1	Transcription Activator-Like Effector NucleasesIBA 10/2016
1	Oxidoreductases (Dehydrogenase)IBA 01/2015
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2015
1	EnzymesIBA 01/2015
1	AP 1903 reagentIBA 01/2014
1	romiplostim FDA Link 07/2013
1	telomerase RNA (bTR)IBA 05/2013
1	Neutralizing AntibodiesIBA 07/2012
1	Factor IX (Coagulation Factor IX)FDA LinkGeneric 07/2012
1	Small Interfering RNA (siRNA)IBA 01/2012
1	Interleukin-2 Receptors (IL 2 Receptor)IBA 01/2012
1	Interleukin-2 (IL2)IBA 02/2011
1	Busulfan (Busulfex)FDA Link 06/2010
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 06/2007
1	Neoplasm Antigens (Tumor Antigens)IBA 06/2007
1	IntegrinsIBA 11/2006

Therapy/Procedure

13	Therapeutics 01/2022 - 03/2006
6	Transplantation 06/2011 - 03/2004
2	Immunotherapy 01/2018 - 06/2011
2	Aftercare (After-Treatment) 01/2018 - 11/2005
2	Homologous Transplantation 07/2012 - 03/2005
1	Blood Component Removal (Apheresis) 12/2020
1	Cell- and Tissue-Based Therapy (Cell Therapy) 12/2018
1	Stem Cell Transplantation 12/2015
1	Platelet Transfusion (Blood Platelet Transfusions) 07/2013
1	Duration of Therapy 11/2007